TECHNOLOGY

Better information on ivermectin is finally on its way


Edward Mills came With very good information at the meeting last month. Mills, a clinical trial specialist at McMaster University, was presenting new results from a trial that looked at how well half a dozen different drugs work with Covid-1 treat নয় not for sick people who are in an emergency room or hospital, but whose symptoms are still bad. Not among them. Sick people at home, in other words.

In its online discussion by the National Institutes of Health, Mills’ slides tell the story: A relatively safe, known, inexpensive drug has reduced the relative risk of mild covid by about 30 percent. The drug is fluvoxamine, a selective serotonin reuptake inhibitor – an antidepressant. (This is an anti-inflammatory, and anti-inflammatory and an over-reactive immune system is a sign of severe covid infection, so it may seem to help). Get a bunch of guys with Kovid and shuffle them into two groups; Get 739 fluoxetine and 733 placebo. Of the fluvaxamine recipients, only 77 ended up in the hospital; 109 of the placebo group. It’s exciting.

“Is this the first time these results have been presented in a public forum?” Duke asked Adrian Hernandez, director and moderator of the Clinical Research Institute.

“Yes,” Mills replied. “This is the first time you’ve heard it.”

“Well, just, wow,” Hernandez said. If the data carries, it will only be the second re-established drug that works for extracellular covid-1 for. (The other is a steroid called budesonide; other drugs you may have heard of, such as remedivir or dexamethasone, people who are critically ill and hospitalized. The Mills trial, on which Mills co-chief investigator, is well-planned and respected. , Fluvoxamine is still a way to avoid being part of the care criteria for people infected with Covid-1. Holds, seems to be positive for SSRI.

But wait! There’s more! In the same presentation, the same trial showing the same antidepressant may reduce the symptoms of covid-1 of Also Showed that the antiparasitic drug ivermectin – you heard of it, didn’t you? – Doesn’t help at all. Together in the trial, the drugs, which are commonly used against things like river blindness and intestinal roundworms, did not keep anyone infected with covid better than a placebo outside the hospital. Of the 7 people who contracted covidia who weighed kil00 micrograms per kilogram per day for three days, 86 were admitted to the ER or hospital; Of the 678 people who got placebo, 95 went. This is not a significant difference, and Mills’ team excluded it from the study. (Vaccines, I should add, are still the most effective, safe, cheap and easy way to avoid getting sick.)

Ivermectin’s Petri dish and small and observational studies had some promising initial results against the virus, but it has yet to enter a trial. Among the two large-scale confirmations of its impact, one (a print by Egyptian researchers) has been withdrawn due to concerns about theft and fake information. BuzzFeed’s scientists and journalists have found irregularities in information obtained from others. A separate, positive review of all of the ivermectin data was rejected from a journal after temporary recognition for the totality of the research totality and conflict of interest, while a rigorous meta-analysis All A randomized controlled trial of ivermectin against covid found no positive effects of the drug. The FDA says people shouldn’t take it. The American Medical Association and two pharmacists’ associations have issued a statement recommending that none of their members prescribe ivermectin for Covid-1 for outside clinical trials. (Oh, and a doctor in Arkansas unknowingly gave prescription drugs to dissenting inmates, which is not usually the history you want to have.)



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